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Friday, March 6, 2009

CONTROL OF BIOAVAILABILITY

Bioavailability is controlled by
1. Rate and extent of drug release from product.
2. Rate of absorption of drug from site of absorption.
3. Rate of drug metabolism during absorption.
RELATIVE BIOAVAILABILITY:
Relative bioavailability refers to the availability of drug as compared to the standard one.
Relative bioavailability is determined by comparing the availability of a drug product to that of standard dosage formulation.
Relative bioavailability of two drug products, given at the same dosage levels and same route of administration, is given by:
(AUC)A
R.A= ----------
(AUC)B

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  4. Achieving the desired Hydrophilic-Lipophilic Balance (HLB) in a formulation development is essential for proper emulsion stability. In some cases, it may be challenging to achieve the exact HLB with specific emulsifiers, as demonstrated in the calculation. Formulators may need to explore alternative emulsifiers or reformulate the product to meet the target HLB effectively.

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