B) Aqueous-non aqueous and mixed vehicles
Water-miscible solvents are widely used to enhance solubility and to serve as stabilizers.
The most common solvents include glycerin, ethyl alcohol, propylene glycol and polyethylene glycol 300. Mixed solvent systems do not exhibit many of the disadvantages observed with the fixed oils, but may be irritating or increase toxicity especially when present in large amounts. A solution containing higher percentage of ethanol produces pain on injection.
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