The particles may localize in lungs, liver, spleen and myocardial tissues and may lead to thrombosis
Particles may lead to myocardial infarction due to embolic fibers.
Injection of solution contaminated with particulate matter causes granulomas and emboli in lungs Compendial requirements
Due to having a potential for blockage of the capillaries, an injection must be free from the visual evidence of particulate contamination. Thus, according to the Compendial requirements, each final container of the injectable must be inspected individually and the container must show evidence of contamination with visible foreign material.
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