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Sunday, March 29, 2009

DETERMINATION OF TOTAL SOLIDS


The term “total solids” is applied to the residue obtained when the prescribed amount of the preparations is dried to constant weight under the conditions specified. Total solids usually include extractives, both soluble and insoluble in alcoholic or hydro-alcoholic preparations as tinctures and extracts.

The total solids are calculated as g/100ml

This test is more preferably performed for the tinctures or galenical preparations containing a higher amount of solid contents.

PROCEDURE:

Take a china dish, weigh it then add 5ml of the tincture or the given preparations.

Heat this to evaporation. Then weigh it again.

Increase in weight is the weight of total solids in 5ml of sample.

Specific ranges are given in pharmacopoeia.

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