Syrups are concentrated aqueous solutions having 66.7 % w/v of sucrose. Syrups also contain aromatic or other flavoring materials.
TESTS FOR EVALUATION OF SYRUPS
Following tests are specified for the evaluation of syrups:
Consistency.
pH determination.
Refractive index.
Identification of active contents.
Assay of active contents.
Solubility.
CONSISTENCY:
Should be clear solution.
There should be no solid particles.
pH DETERMINATION:
Determine the pH of syrup by suitable means; it should be 6.0 to 7.0.
REFRACTIVE INDEX:
The value of refractive index should be in the range of 1.4608 to 1.4630.
IDENTIFICATION OF ACTIVE CONTENTS:
Identify the active contents of syrup by suitable means e.g. invert syrups dissolve with 10 ml of water and 5ml of potassium cupric tartarate solution. A red precipitate is produced.
ASSAY OF ACTIVE CONTENTS:
For example, Lemon syrup.
Mix 8 grams with 100ml of water and titrate with 0.1M NaOH using phenolphthalein as an indicator.
Each ml of 0.1M NaOH=0.007005 grams of C6H8O7.H2O
SOLUBILITY:
Soluble in water.
Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Linezolid using ion exchange resin and to formulate the dry syrup of the taste masked drug. If you want better manufacturing company for Dry Syrups Manufacturer India is well known country for Dry Syrups.
ReplyDelete