(C) INHIBITION OF PEPTIDOGLYCAN PRECURSOR SYNTHESIS

Many drugs such as bacitracin inhibit different early steps in the biosynthesis of peptidoglycan. As the early stages of synthesis takes place inside the cytoplasmic membrane, these drugs must penetrate the cell membrane to reach the interior of the cell to produce their effect. For example Cycloserine, an analogue of D-Alanine, blocks the action of Alanine racemase, the enzyme necessary for incorporation of D-Alanine in the pentapeptide of the peptidoglycan.